Sunday, August 31, 2008
As you move into the next age group (25-44) notice that the overall mortality rate almost doubles (178 per 100,000) but that's still quite low. The carnage on the roads continues but AIDS, Cancer and heart diseases are moving up.
As we move into the 45-64 age group the death rate starts to rise sharply, up to 700 per 100,000. Mainly due to rising rates of heart disease and cancer. If you look at the final category of 65+ you'll see Pneumonia and Influenza crack the top 5.
I was thinking about this today because of the sad news that a 66 year old Santa Barbara woman, out running, was hit by a drunken driver early yesterday morning. I assume this will go down in the statistics as a motor vehicle 'accident'.
So please drive, walk and bike safe this labor day. And every other day for that matter. Even in our quiet paradise town by the sea there are drunks on the road at 7.30 in the morning.
This has been your labor day public service announcement.
Saturday, August 30, 2008
This is part of the US army regulation covering scientists working on bioweapons. (Actually bioweapon 'defence' since the US doesn't work on bioweapons).
Unfortunately it appears that this modest list of conditions - which, let's face it, isn't that different to the characteristics you might look for in a date - is too much for the workers at the US Army Medical Research Institute of Infectious Diseases (USAMRIID). In 2007 the deputy commander for safety wrote:
'The possibility of losing talented and well-trained researchers to other facilities.... with less stringent programs.... may impact the ability of the Defense Threat Reduction Agency to provide research personnel to combat biological agent use.'
This is all coming to light now because of the case of Bruce Ivins, accused of killing five people in the anthrax attacks of October 2001. Regardless of how fishy you think the whole thing smells a big question needs to be answered - how can we prevent our own bioweapon 'defence' labs from being the source of bioweapon attacks? There have been a few articles along this line but we need a much bigger debate on this and whether the huge expansion in 'biodefence' facilities will cause a greater risk than the risk of a terrorist or other bioweapon attack they seek to prevent.
Friday, August 29, 2008
Thursday, August 28, 2008
First up is the Global Atlas of Infectious Disease, I did get quite a few broken links there but there's still some nice maps in the infectious disease section.
The Worldmapper website takes an interesting approach to mapping geographic data. It uses an algorithm that distorts the size of the country to represent the value of interest. The example shown below is HIV prevalence (proportion of people 15-49 with HIV). They have a number of such maps for diseases (eg TB, Cholera, Rabies, Influenza etc) and a whole range of other categories.
Wednesday, August 27, 2008
Plum Island, New York
Butner, North Carolina
San Antonio, Texas
The new lab will essentially replace the current Plum Island animal disease center, which does not have a BSL-4 lab. One option is to build it on the Plum Island site but the cost of this is much higher.
Choosing the location for the facility is creating some tension between the local residents, who don't want the lab and local politicians, businesses and universities who do want the lab, either for the research possibilities it would provide or the money and jobs it would provide, or both. The average cost for the six finalists is $721 million. Residents in Athens, Georgia who don't want the lab there have a very active website, as do opponents of the lab in North Carolina and Kansas. What do you think? Is this just nimbyism? FYI, the University of California submitted an 'expression of interest' in hosting the lab but was not invited to submit a full proposal by the Department of Homeland Security. UC's plan was to build the lab at the Lawrence Livermore National Laboratory.
Tuesday, August 26, 2008
First up, we've already mentioned. Clostridium perfringens as the causative agent of gas gangrene - a major cause of death in World War 1.
You might also have heard of Clostridium botulinum, or at least of the disease it causes - botulism. Botulism is a paralytic food poisoning that is fortunately rare. The bacteria grow on food and cause harm in people as we digest a toxin produced by the bacteria. The neurotoxin is one of the most powerful toxins known to man, a single microgram is lethal. It is also used (in minute doses!) in the cosmetic treatment known as Botox.
Clostridium tetani is the causative agent of tetanus. The symptoms, muscle spasms and difficulty swallowing are caused by a neurotoxin produced by the bacteria. Infection generally occurs through wound contamination, and often involves a cut or deep puncture wound. Infection can be prevented by immunization, and this is often successful even if given after the wound occurs. Which is why it's a good idea to get a tetanus shot after a deep cut or puncture wound. If you wait to see if an infection develops it is too late for immunization to be much use.
The final member of our happy little Clostridium family is Clostridium difficile. C. difficile, or just C. diff. is the latest, greatest threat in nosocomial infections and there have been numerous outbreaks lately. Try a google news search on Clostridium difficile to see where the latest outbreak is (Canada apparently). C. diff is an interesting bacteria because it is found as a natural part of the gut flora in a small fraction of people, usually with no problems. But if the usual gut flora is eradicated with broad spectrum antibiotics C.diff can greatly increase in numbers and release toxins that cause severe diarrhoea and death in some cases. Some new strains appear to be producing much more toxin. Hospitals are very good places to find people taking broad spectrum antibiotics and, apparently, are good at spreading C.diff around as well. There was an MSNBC article with the subhead ‘C. diff’ rivals MRSA as the next deadly bacteria threat, experts say' in May of this year.
Monday, August 25, 2008
First, the correct bit. Yes, in answer to the question, HIV and other retroviruses contain genes that code for the reverse transcriptase they need to replicate.
However I think I then said that reverse transcriptase would not normally be found in human cells. (After all it's called reverse transcriptase for a reason - transcription usually goes from DNA to RNA).
But I was totally forgetting about transposons, in particular, a type of transposon called a retrotransposon. You might have heard of transposons referred to as 'jumping genes' for their ability to move about within the genome. Retrotransposons achieve this trick by being transcribed to RNA and then back to DNA in their new position. This transcription from RNA back to DNA occurs via, you guessed it, a type of reverse transcriptase. Since their discovery in the 1980's it has been found that retrotranspons are common in the genomes of animals and, in particular, plants.
Targeting reverse transcriptase is still a viable strategy for HIV drugs though and HIV drugs such as Retrovir, Epivir, Viread and Viramune are all reverse transcriptase inhibitors.
In a link to earlier lectures, transposons in bacteria can carry genes for antibiotic resistance and are capable of moving these genes from chromosomal DNA to plasmid DNA and back again. This is an important mechanism in the acquisition of multi-drug resistance.
This might be a bit much biology for some of you but I thought it was interesting.
Relevant material previously on the blog:
Endogenous retroviruses (read the New Yorker article on endogenous retroviruses, it's excellent)
The Lost Children of Rockdale County (links to the PBS program I referred to in class)
STD versus STI
Sunday, August 24, 2008
Malaria Researchers Identify New Mosquito Virus
Researchers at the Johns Hopkins Bloomberg School of Public Health's Malaria Research Institute have identified a previously unknown virus that is infectious to Anopheles gambiae—the mosquito primarily responsible for transmitting malaria.
Although the virus does not appear to harm the mosquitoes, the researchers determined it is highly infectious to mosquito larvae and is easily passed on to the adults.
In theory, we could use this virus to produce a lethal toxin in the mosquito or instruct the mosquito to die after 10 days, which is before it can transmit the malaria parasite to humans. However, these concepts are many years away.
Some Cells Self-destruct For The Greater Common Good.
'(R)andom molecular processes during cell division allow some cells to engage in a self-destructive act to generate a greater common good, thereby improving the situation of the surviving siblings.'
Normally, salmonellae grow poorly in the intestine because they are not competitive with other bacteria of the gut. However, this dynamic changes if salmonellae induce an inflammatory response, namely diarrhoea, which suppresses the other bacteria. The inflammation is triggered by salmonellae penetrating into the intestinal tissues. Once inside, salmonellae is killed by the immune system. This in turn creates a conflict: salmonellae are either suppressed by the other bacteria in the gut, or die while trying to eliminate these competitors.
As Ackermann, Hardt and Doebeli report, salmonellae have found a surprising solution to this conflict. Inside the gut, the samonella bacteria forms two groups that engage in job-sharing. A first group invades the tissue, triggers an inflammation, then dies. A second group waits inside the gut until the inactivation of the normal intestinal flora gives them an opportunity to strike. This second group then multiplies unhindered.
Zoonoses as Biological Weapons
Saturday, August 23, 2008
On a totally unrelated note, did anyone else watch the Olympic men's marathon? 75 degrees at the start, 85 degrees at the end, 50% humidity and the winner simply outlasts everyone else at an insane pace to finish in 2:06:32, only a couple of minutes outside the world record, on a hot and sticky course, and then says:
"I had to push the pace because my body gets tired when I slow down."
Okay, that's my problem right there, I tend to get tired when I speed up. I knew I was doing something wrong.
Friday, August 22, 2008
How would such a thing be possible you ask? Simple, the vaccine would prevent you from transmitting the disease but would not prevent you from getting it. Assuming the vaccine had some level of side effects - say 1 in a million actually get AIDS from the vaccine - what do you think the rate of uptake would be?
Sad to say, I'm guessing it would be very low (<1%). People, they ain't no good. In fact I'm guessing that even with NO side effects the rate of uptake would be low. I'm not sure what the R0 for HIV is, but let's imagine that there needs to be 75% coverage to establish herd immunity. IF such a vaccine were possible should the government introduce legislation to make vaccination mandatory? Or would it be sufficient just to offer an incentive? How much? $10, $100, $1000? Should individuals who contract AIDS from the vaccine be compensated or did they accept this risk when they agreed to be compensated? Do you think we could realistically ever achieve a 75% vaccination rate?
And then just to make this more complicated, imagine this was a decision you were making not for yourself but for your children.....
Thursday, August 21, 2008
As I think I wrote on an earlier post I'm not a vegetarian and don't have any particular agenda here. On the other hand, in the interests of full disclosure, I should say that since first doing some research about this issue in the mid-1990's I haven't actually felt like eating red meat....
If this had been a few days earlier I would have considered using it as a exam question: 'Rewrite this article as if you had some basic understanding of herd immunity.'
There will always be some fraction of the population that cannot be immunized. However if a sufficient proportion of the rest are vaccinated those who cannot be vaccinated (who probably have more serious problems to worry about) are protected. So, not getting children vaccinated is not just a (probably misguided) attempt by parents to reduce their child's overall risk - it is also a selfish act that should be labeled as such.
(Of course I'd probably feel totally different if I actually had children myself. But I don't. I have a dog though and he's vaccinated.)
Wednesday, August 20, 2008
For the Tuesday section, I'm posting the parts for the role play for next week in the links section on the blog. The role play is called An Outbreak in Zentonia. The panel members are: a medical doctor, a disease ecologist, a newspaper reporter, a US congress member, a citizen in Zentonia, and an environmentalist. Please select a part that you would like to play for next week. Additionally, you may choose to be an audience member ONLY IF YOU WERE A PANEL MEMBER LAST ROLE PLAY. If you were in the audience last time, you must choose a panel part this time.
To print your part, open the Word document from the link provided, and scroll down. The first page is the introduction and moderator part (that's me). The next few pages are the audience part. After that you will find one page for each part as you scroll down: the role is listed about halfway down each page under the heading "Your role."
My goal for this week is for everyone to really stay in their role. Try selecting a role that you don't necessarily agree with, and play Devil's Advocate. It's fun, and it'll make the discussion more interesting, since many of us may actually have similar opinions.
Tuesday, August 19, 2008
Relevant material previously on the blog:
Mad Cow USA
Sexually transmitted Lyme Disease ?
World's worst mouse plague
Monday, August 18, 2008
This week in section we will be discussing the interplay between disease and culture. We've already talked in lecture about several instances of culture/behavior impacting disease transmission. For example, boarding up windows in nineteenth century London kept the "miasma" out and the Tuberculosis bacteria in. Likewise, as mentioned today, people who like to hike around and live in rural, wooded areas in the Northeast are at greater risk for Lyme disease.
Sexually-transmitted diseases like HIV/AIDS are ripe with potential for both cultural differences in transmission and disease impacts on culture. Some reports (from research done mostly in Kenya and Uganda) have shown that circumcised men are around 50% less likely to contract HIV from heterosexual sex. In these countries, where circumcision in infancy is not the norm, the clinical trials involved circumcising adult men in a safe medical procedure. Many people may not know that in western countries, the female-to-male sexual transmission rate of HIV is very low (as shown in studies like this one). In a sense, western (American and European) females are essentially a dead-end host for HIV, since they can get the virus sexually from men but do not pass it on. Most of infected men contract HIV either by having sex with men or through intravenous drug use. On the other hand, women in Africa seem to be a more competent host, and African men contract HIV from heterosexual sex much more readily there. Though the scientific community does not yet know why, some reports suggest that this may be related to circumcision rates and concurrent STIs.
Finally, another huge source of new HIV cases in the US is from intravenous drug users (IVDUs, in the public health lingo). Australia has addressed this problem by creating needle-exchange programs that allow intravenous drug addicts to get clean needles. The US has thus far refused to adopt this strategy, which Australian National Affairs Editor Mike Steketee argues is a case of "ideology sometimes get[ting] in the way of saving lives." Is giving out clean needles as a public service antithetical to the "War on Drugs"? Does it promote drug use, or save lives? A similar ethical issue surrounds the question of whether or not to give school kids access to condoms in conjunction with sexual education. These are all direct ways in which our own culture may facilitate or inhibit disease transmission.
Relevant material previously on the blog:
Lyme Disease and President Bush
Now THAT'S what I call an ecosystem service.
Attack of the Lone Star
The Lyme Disease Controversy
Sunday, August 17, 2008
Unfortunately it appears that these very useful and widely used drugs may have a number of serious side effects. Just last month the FDA ordered their strongest "black box" label warning to alert patients to the danger of possible tendon ruptures and tendonitis.
The FDA is not releasing numbers but apparently there have been 'hundreds' of cases of Achilles tendon ruptures. Obviously there is an interaction with lifestyle here, and those that are physically fit, and put pressure on the Achilles tendon are most likely to be injured.
'Sometimes patients have no symptoms before they experience a rupture in their tendon -- commonly their Achilles tendon. Sometimes it's been reported on the first day of taking a fluoroquinolone ... a sudden snap or popping sound that is tendon rupture with no preceding warning.'
So, if you have to take an antibiotic for any reason, do your homework. Look up the side effects. If it seems you are at extra risk for those side effects (like you run or play a sport) then you might want to ask your doctor if there are alternatives. Quinolone antibiotics associated with tendonitis and tendon rupture include Cipro and generic ciprofloxacin, Factive (gemifloxacin), Levaquin (levofloxacin), Avelox (moxifloxacin), Noroxin (norfloxacin), and Floxin and generic ofloxacin.
Friday, August 15, 2008
Back to the midterm.....
Oh, and there are some sample questions up. Check the link box at the top right.
This story literally hits close to home. The study finds that there have been 18 XDR and 77 pre-XDR cases in California in the last fifteen years. Most of them have been the result of improper Tb treatment (lack of medical supervision, misprescription of second-line drugs, etc) or HIV infection.
There's also an extensive article in the New Yorker about "Superbugs" that summarizes a lot of what we've learned about MRSA and other antibiotic resistant bacterial strains, especially those found in hospital ICUs. The amount of work and care required to sanitize a ward of Tisch Hospital at NYU infected by a completely resistant Klebsiella pneumoniae strain is impressive.
Thursday, August 14, 2008
By moving through the coffee via the empty spaces between the ground coffee particles, the water picks up the flavour of the coffee. Stephen Davis and colleagues at the Faculty of Veterinary Medicine, Utrecht University, report in Nature their discovery that the spread of the bubonic plague bacteria in Central Asia by gerbils, works much the same way.
Plague bacteria percolate through the landscape transmitted by fleas from one great gerbil family to the next, from burrow system to burrow system. It’s the first time percolation theory is used to accurately describe the natural dynamics of an infectious disease. The discovery might be helpful to understand how outbreaks of disease occur in other populations. It may, for example, shed new light on spread of bovine tuberculosis in badgers, and spread of viral diseases in populations of African lions.
The only thing that bugs me about Science Daily is that they don't seem to provide direct citations to the source articles - just a couple of hints like the authors name and journal. It usually isn't hard to track down but I don't know why they don't give the full citation. Here's a link to the original paper - The abundance threshold for plague as a critical percolation phenomenon. It has a lot fewer references to coffee but it does have a very cool satellite photograph of gerbil burrows.
Wednesday, August 13, 2008
You can watch the whole show at the site, or download it as an mp3 file to listen to, and also read an interview with a 'vaccine expert' that raises interesting issues and find out the basic facts about HPV and the vaccine. If you can't see what all the fuss is about take a deep breath and read some of the posted comments.
Also, over the next couple of days I will be writing the midterm and will post some sample questions here. I'll also put up a cumulative list of the terms we have covered to date (ie a subset of the larger glossary) which might be useful.
Relevant material previously on the blog:
Well, this post actually but I wanted to draw particular attention to it.
Solver for the SIR Model of the Spread of Disease
The height of reckless irresponsibility
Tuesday, August 12, 2008
Just to clarify, you will only be assigned to read ONE of the two papers for next week (either the Lafferty paper or the Fincher et al. paper)--Wednesday people, you will understand this tomorrow. I posted both papers on the blog in case you lost your copy I handed out or in case you were interested in reading both.
I realize that these papers might be a bit challenging (especially the methods section) for some of you who aren't very familiar with reading scientific papers. In my opinion that is part of the value of the exercise! However, if you're having trouble understanding part or all of your paper, please feel free to email me at firstname.lastname@example.org in the next week with questions. I want this to be a rewarding (not frustrating!) experience.
Also, to enhance our discussion, be thinking over the next week about examples of how cultural practice impact disease transmission, and how disease prevalence may in turn impact the development of human culture. Religious food and clothing taboos are interesting, for instance...
'No single smallpox pandemic was as devastating as the Black Death, but the cumulative toll of human life caused by smallpox constituted an even stronger selection pressure than the episodic decimation of bubonic plague.'
Relevant material previously on the blog:
The Great Chinatown Fire
Flagellation in German rock video
Plague as a Biological Weapon
However on one pedagogical issue I have to respectfully disagree. In the 'Contents, preface and pedagogy' section of the textbook he writes:
'I avoid cartoons and other images that suggest the student is "just a kid".'
Well as you've doubtless noticed I love cartoons. They aren't there to entertain the kid in you, they are there because they act as a sort of mirror that reflects back an exaggerated version of societies concerns, fears and opinions. A good political cartoon can skewer a politician much more effectively than much lengthier editorial columns. For the best in political cartooning check out Daryl Cagle's webpage where he collects all the daily editorial and political cartoons and indexes them by category.
Society is also reflected back in some of the strips in the funny pages. The ongoing, and usually interminable, soap-opera strips sometimes throw up surprising diseases stories. Months ago Rex Morgan M.D. started a tedious MRSA (Methicilin resistant Staphylococcus aureus) storyline that has only just wrapped up. I just checked and this storyline started sometime back in March. ..
I was reminded of all this because Mark Trail this weekend was reminding us to check our animals for fleas lest the Bubonic Plague visit us again.
Monday, August 11, 2008
In both cases the equestrian events were held in a different IOC member states - but for opposite reasons. In 1956 the equestrian events were held in Stockholm because Australia's quarantine laws were so strict it would have seriously affected the ability of countries to bring horses into Australia. China was awarded the 2008 games, despite concerns about human rights, and about pollution but almost totally unreported by the press was the fact that the equestrian events would have to be held in Hong Kong because of concern about horse diseases in China.
If you google the term you'll see this is quite a hot topic. A google news search throws up this article from a couple of weeks ago:
Environmental Group Calls Triclosan a Ubiquitous Menace
This presentation, Antibacterial Household Products: Cause for Concern by Stuart Levy, from the 2000 Emerging Infectious Diseases Conference in Atlanta, Georgia and on the CDC webpage is a good overview of the resistance issue.
Relevant material previously on the blog:
Minié balls and infection before penicillin
XDR-TB in South Africa
Pollution and Antibiotics
Douglas Manor, in Queens, New York, is known for its old-timers who swim in the salt water of the bay for their health. Many of these residents have been swimming in the bay for over fifty years, and locals claim that the neighborhood has had a tradition of swimming since the 1800s. Ironically, although the residents of Douglas Manor believe that swimming in the bay is good for their health, the bay actually has high levels of fecal contamination, and local health authorities often issue warnings against swimming in the bay after heavy rains. The stubborn old folks, known as the Floating Heads, often ignore these warnings and insist that "no one has ever gotten sick swimming in this bay" or that "the city posts the advisories for liability sake, so they can’t get sued if someone says they came down sick from swimming.” Other swimmers simply insist that they don't swallow the water while swimming. Is that sufficient to protect the body (especially an elderly body) against infection by fecal-borne microbes?
The Times article states that "Douglas Manor, an almost entirely residential area, is one of the few neighborhoods in the city without a sewer system. Opinions vary as to whether cesspools or sewers better contain sewage outflow to waterways during rainstorms." If only the Times could interview Joseph Bazalgette about the relative advantages of sewers versus cesspools.
Sunday, August 10, 2008
Maggot therapy is an old idea where fly larvae are used to clean out wounds. This sounds gross but because most fly larvae only feed on dead tissue it is actually a surprisingly effective technique. Some of the most widely documented cases come from the US civil war where numerous cases were observed of soldiers left for days on the battlefield who actually fared better than those who had been in hospital - because fly larvae had debrided their wounds. Certain surgeons, most notably a confederate medical officer, Joseph Jones. started actively using maggots to clean wounds.
"Maggots.. in a single day would clean a wound much better than any agents we had at our command ... I am sure I saved many lives by their use. "
Because of the current problems with antibiotic resistance hundreds of healthcare centers are now investigating and using maggot therapy. UC Irvine is a US hotbed of maggot therapy and has a webpage with all the information, links and references you are likely to need.
Research by British workers published last week describes the isolation of compounds from the maggots that have antibacterial properties.
"Maggots are great little multi-taskers. They produce enzymes that clean wounds, they make a wound more alkaline which may slow bacterial growth and finally they produce a range of antibacterial chemicals that stop the bacteria growing.”
There's a short National Geographic video about Maggot therapy available on YouTube if you want to see some maggots in action. It's not super-gross but be warned it does contain maggots, an open wound, and maggots in an open wound.
Saturday, August 9, 2008
Eventually it was worked out that the vultures were dying because of a drug, diclofenac, commonly used in livestock. Vultures fed on livestock, ingested the drug, and died.
Now a new study, published in Ecological Economics this week, suggests that this loss of vultures may have led to an additional 50,000 rabies deaths in India. As the vulture numbers declined so the number of feral dogs increased. India has one of the world's highest incidences of rabies. and some of these dogs would have been infected with rabies. Calculations suggest an additional 5.5 million feral dogs between 1992 and 2006 leading to an additional 38.5 million dog bites. In India 123 people die of rabies for every 100,000 dog bites. This suggests at least 47,300 people died of rabies as a result of the vulture die off. Rabies is a very nasty viral disease which has a very high fatality rate. In fact, once symptoms develop, death is practically inevitable. There are only six known cases of a person surviving rabies once symptoms have developed. The best chance of surviving rabies is a prompt post-exposure vaccination that may prevent the virus from progressing to the symptomatic stage.
There is some evidence that vulture numbers may, in some areas of India, be starting to increase after the widespread use of diclofenac was discontinued.
Friday, August 8, 2008
#1 A new report by the Centers for Disease Control and Prevention (CDC) shows the number of new HIV infections in the US is actually higher than previously estimated. The agency recently adopted improved statistical techniques that indicate that 56,300 people in the US contracted AIDS in 2006, up from the estimate of 40,000 that the agency has commonly cited as the annual infection rate.
#2 The death rate due to AIDS is so high in Uganda that a Ugandan official has suggested to MPs that funerals should be limited to Saturday afternoons to stop people taking time off work to attend them.
#3 British celebrity chef Antony Worrall Thompson has apologised after accidentally recommending cooks use a potentially deadly plant in organic salads. Thompson said he had confused henbane with a different plant. Presumably one that does not cause vomiting, convulsions and death.
Thursday, August 7, 2008
Lecture slides are posted as pdf files usually within about half an hour of the end of the lecture to the right of this page. The glossary is also there and the syllabus plus your democratically agreed upon section rules and expectations.
Next week we will talk more about antibiotics and antibiotic resistance before moving on the the ever popular Bubonic Plague and a brief discussion of how the model diseases.
1733 Swift Poems II. 651
In the latest illustration of Swift's rule scientists yesterday published the first description of a giant virus that falls ill through infection by another virus.
This is re-igniting a debate about whether viruses are 'alive' or not “The fact that it can get sick makes it more alive.”
The giant virus which serves as the host (known as mamavirus), is itself found within single celled amoebae. A study of ocean water has revealed an abundance of genetic sequences closely related to giant viruses, leading to a suspicion that they are a common parasite of plankton.
“I think ultimately we will find a huge number of novel viruses in the ocean and other places,” Suttle says — 70% of viral genes identified in ocean surveys have never been seen before. “It emphasizes how little is known about these organisms — and I use that term deliberately.”
This isn't directly relevant to what we've been discussing this week, but the blog is also a place for breaking news.
Wednesday, August 6, 2008
Speaking of well-known sewer systems, there is an urban legend that alligators once inhabited the Manhattan sewer system. The story goes that short-sighted New Yorkers would vacation in Florida and bring back adorable baby alligators as pets. Unfortunately, when these pets grew beyond their owners' control, panicked parents would flush the alligators down the toilets, leading to colonies of subterranean alligators living in the sewer systems. These alligators somehow eventually lost their eyesight and became albino (or so did their progeny, in some feat of rapid and potentially Lamarckian evolution). They are also reputed to protect the stash of "New York white" albino marijuana, also rumored to grow in New York sewers. Thomas Pynchon gives credence to these rumors in V. by giving Benny Profane a job wrasslin' gators in the New York sewer system. None of these tall tales, however, are thought to be true.
Tuberculosis is one of the leading causes of death in people with HIV, resulting in an estimated13 percent of AIDS deaths worldwide. As Véronique LaCapra reports, doctors working with the World Health Organization stress the need to coordinate the response to these two catastrophic epidemics, and to integrate TB screening and treatment into HIV care.
The report is inspired by, and refers to, this paper in the Journal of the American Medical Association: Opportunities and Challenges for HIV Care in Overlapping HIV and TB Epidemics
Relevant material previously on the blog:
Tuberculosis and vampirism
Tuesday, August 5, 2008
From an AP article in the Houston chronicle last week. Two-thirds of the raw sewage in the capital flows untreated into waterways and residents in parts of the city still get their drinking water from the river.
"Iraq is on the cusp of a serious water crisis that requires immediate attention and resources," said Thomas Naff, a Middle East water expert at the University of Pennsylvania.
The World Bank has estimated that it would take $14.4 billion to rebuild the Iraqi public works and water system.Relevant material previously on the blog:
The ghost map
Expecting the unexpected
Monday, August 4, 2008
World Toilet Day is the 19th November every year and is the brainchild of the World Toilet Organization - a global non-profit organization committed to improving toilet and sanitation conditions worldwide.
I heard of it via this article on providing sanitation and clean water in Bangladesh on the WaterAid website. Browsing these charity websites makes you realize how deadly serious this topic is. It isn't just cholera that is transmitted via contaminated water....
If you are interested in raising money for charity or giving money to charity then it is interesting to consider where the best 'value for money' is. In terms of saving lives charities that provide clean water and sanitation would have to rank very highly.