Thursday, March 10, 2011
After an outbreak of Avian Influenza in India veterinatires. In Tripura in a state-owned poultry farm in Ganhigram, veterinarians started to cull their chickens. This farm is one of the main breeding centers and it has a capacity of around 7,000 chickens.
Samples were sent to the High Security Animal Disease Laboratory in Bhopal after 380 birds died between March 1 and March 4. The samples tested for HIN5.
The culling is going to continue for the next few days in order. They people in charge of the poultry farm announced that they still have 1,400 Japanese peahens and 20,000 eggs that have to be dumped. Also the poultry in the surrounding 10 Km would be culled as well.
This is not the first time this outbreak has occurred in India. The last time there was an outbreak was in 2006.
A paper in PLoS ONE in January this year, Thermal Image Scanning for Influenza Border Screening: Results of an Airport Screening Study, looked at a sample of 1275 airline passengers who agreed to be screened, have their temperature actually measured and give a respiratory sample. Six of the travellers had a fever and thirty of the travellers tested positive for influenza. But none of the influenza-positive travellers had a temperature high enough to be considered in the fever group!
Our findings therefore suggest that ITIS is unlikely to be effective for entry screening of travellers to detect influenza infection with the intention of preventing entry of the virus into a country.
I'm sure we'll see more of these thermal scanners in airports in future pandemics even if they are fairly useless. Why? Because it makes it look like somebody is doing something (even if it is useless). Just like the rest of airport security
As the government releases 600,000 doses of the H1N1 vaccine today, predatory online “pharmacies” are dispensing junk medicine to a frightened public.
With the first 600,000 doses of swine flu vaccine scheduled to be released today and the media already swirling about how difficult it will be to get a dose, scam artists from Internet “pharmacies” are lining up to bridge the gap.
Specifically, the U.S. Food & Drug Administration, the World Health Organization and the pharmaceutical industry are bracing for an onslaught of fake and substandard drugs, with a special eye out for unauthorized versions of Tamiflu, the patented Roche vaccine that is the cornerstone of the public health-effort. “We don’t know what we could be seeing in the next few weeks,” says Gary Coody, who coordinates health-care enforcement for the FDA. “They (Internet drug operators) don’t necessarily have any regard for public-health safeguards.”
full blog post: "Swine Flu Swindle"
Wednesday, March 9, 2011
I'll keep posting until Friday and then I'll wrap up with some review questions etc.
An article published in Science Daily today reveals that a mutation in the H1N1 strain of influenza virus (aka "swine flu") may allow it to become more easily transmitted from person to person. The strain of flu that the WHO declared a pandemic back in 2009 is actually a mixture of human, bird, and pig influenza genes. Despite the enormous amount of media attention it got, it proved to not be significantly deadlier or more debilitating than the seasonal flu humans encounter nearly every year. The swine flu proved to be relatively inefficient at moving from person to person... until now. Researchers at MIT have discovered a mutation that may allow this flu virus to transmit much more rapidly and effectively from person to person. A potentially deadly mutation to the virus' hemagglutin has been identified, but this should allow to WHO to quickly identify any outbreaks of the potential new strain and determine how deadly it can be. MIT scientists merely altered 1 amino acid chain that allowed the Hemagglutin to bind much more strongly to respiratory cells, increasing its ability to infect as well as kill humans. They identified this mutation as being a very possible one for the swine flu to evolve into. As the article is quick to point out (namely, the first few sentences), this potential two-wave pattern of flu outbreak is similar to the infamous 1918 Spanish Flu, which killed around 50 million people. Keep your fingers crossed everyone.
Tuesday, March 8, 2011
“Bill Gates’s obsession with polio is distorting priorities in other critical BMGF areas. Global health does not depend on polio eradication.” (The initials are for the Bill & Melinda Gates Foundation.) -- Richard Horton, editor of The Lancet
“We ought to admit that the best we can achieve is control.” -- Arthur L. Caplan, director of the University of Pennsylvania’s bioethics center, who himself spent nine months in a hospital with polio as a child.
Gates counters: “These cynics should do a real paper that says how many kids they’re really talking about. If you don’t keep up the pressure on polio, you’re accepting 100,000 to 200,000 crippled or dead children a year.”
Right now, there are fewer than 2,000. The skeptics acknowledge that they are arguing for accepting more paralysis and death as the price of shifting that $1 billion to vaccines and other measures that prevent millions of deaths from pneumonia, diarrhea, measles, meningitis, and malaria.
“And think of all the money that would be saved,” Mr. Gates went on, turning sarcastic. “It’d be like 5 percent of the dog food market in the United States.” (Americans spend about $18 billion a year on pet food, according to the American Pet Products Association.)
“If we fail, we’ll be consigned to continuing expensive control measures for the indefinite future,” said Dr. Thomas R. Frieden, director of the Centers for Disease Control and Prevention, which leads the country’s effort.
The article also points out some of the differences between polio and smallpox that have made polio so much harder to eradicate.
One injection stops smallpox, but in countries with open sewers, children need polio drops up to 10 times. Only one victim in every 200 shows symptoms, so when there are 500 paralysis cases, as in the recent Congo Republic outbreak, there are 100,000 more silent carriers. Other causes of paralysis, from food poisoning to Epstein-Barr virus, complicate surveillance. Also, in roughly one of every two million vaccinations, the live vaccine strain can mutate and paralyze the child getting it. And many poor families whose children are dying of other diseases are fed up with polio drives.
Not an easy debate to choose a side in, at least for me...
Genetically altered mosquitoes that cannot fly may help slow the spread of dengue fever and could be a harmless alternative to chemical insecticides, U.S. and British scientists said on Monday. [Feb 22, 2010]
They genetically altered mosquitoes to produce flightless females, and said spreading these defective mosquitoes could suppress native, disease-spreading mosquitoes within six to nine months.
There is no vaccine or treatment for dengue fever, which is endemic in the tropics and is particularly prevalent in Asia and the western Pacific. The disease, which causes severe flu-like symptoms and can kill, is spread through the bite of infected female Aedes aegypti mosquitoes.
"This could be the first in a new wave of products that might supplant insecticides," researcher Anthony James of the University of California, Irvine, said in a telephone interview.
James's team, including a group from the British biotechnology firm Oxitec Ltd., altered mosquito genes to disrupt development of the insects' wing muscle.
The genetic modification grounded only the virus-carrying females and did not affect the males' ability to fly, they wrote in the Proceedings of the National Academy of Sciences here
The idea would be to distribute tens of thousands of eggs that would hatch out these genetically modified males, that would proceed to create a new generation of flightless, and thus doomed, daughters.
Because eggs are so small and easy to distribute, there would be far more genetically modified mosquitoes than natives, so they could in effect blot out the dengue-carrying population.
Google has been tracking flu trends for some time by analyzing people's choice of search terms. This method has been very successful and they can usually pick up trends a few weeks before the CDC data. In 2009 a variety of workers from Google and one from the CDC published a paper in Nature describing their technique: Detecting influenza epidemics using search engine query data.
For epidemiologists, this is an exciting development, because early detection of a disease outbreak can reduce the number of people affected. If a new strain of influenza virus emerges under certain conditions, a pandemic could ensue with the potential to cause millions of deaths (as happened, for example, in 1918). Our up-to-date influenza estimates may enable public health officials and health professionals to better respond to seasonal epidemics and pandemics.
The graph above shows, for the United States as a whole, that the peak flu season is usually in February and that we are probably past the peak this year. You can also see how unusual last year was, pandemic years are always different. The big peak in October is from 2009-2010. The same pattern was seen in California except that our peak flu season seems a bit less predictable.
Monday, March 7, 2011
In the first: Bacillus anthracis comparative genome analysis in support of the Amerithrax investigation, they describe how genomic analysis was used in the investigation of the 2001 anthrax attacks.
The paper describes how the Institute for Genome Sciences faculty and collaborators from the FBI found that the anthrax samples used in all the attacks were genetically identical. Later, another group of scientists -- also including Institute for Genome Sciences faculty -- would trace the anthrax spore used in the letters back to a flask of Bacillus anthracis and several samples taken from that flask. The primary custodian of the flask was Bruce Ivins, Ph.D., a scientist at a U.S. Army biodefense laboratory in Maryland. With this key investigative lead from the scientific team, the FBI used additional police work to conclude that Dr. Ivins was the perpetrator of the mail attacks. Dr. Ivins killed himself before the case could go to court. The FBI has since closed the Amerithrax investigation. (From a report at ScienceDaily)
In the second paper, Hybrid influenza viruses may have pandemic potential, which is relevant to this weeks discussion, the authors describe how the H1N1 strain that caused the 2009 pandemic, but relatively few deaths, may yet turn out to be problematic.
The H1N1 influenza virus that spawned the 2009 pandemic is now predicted to circulate as a seasonal flu. However, researchers fear it could once again present a major public health threat by recombining with the H9N2 virus, which is endemic to several bird species in Asia, and has infected pigs and humans. Yipeng Sun et al. explored this possibility by dissecting the H1N1/2009 and H9N2 influenza viruses, and systematically mixing their genes to generate 127 hybrid viruses. The authors then tested the hybrid viruses in mice to assess the likelihood that genetic reassortment between H1N1/2009 and H9N2 could create a virus of pandemic proportions. More than half of the hybrid viruses instantly infected mice and replicated as efficiently as did the parent strains. Eight of the hybrids proved more virulent and dangerous than did either of the two parent strains. Curiously, each of these eight strains carried a gene encoding part of the RNA polymerase, known as the PA gene, from the pandemic H1N1/2009 virus. The authors suggest that the pandemic PA gene may play a key role in the virus’s pathogenicity, and that screening H9 viruses for the gene might help identify influenza viruses that pose a public health risk.
When we covered Malaria in class, we discussed the helpfulness of Insecticide Treated Nets and learned about non-profit organizations focused on ending Malaria, which raise money to send these nets to infected countries. However, one student shared that he visited one of these countries and learned that the nets are actually stolen by fishermen and are not reaching the people who need them most. After doing some research, I found that the student was absolutely right: these nets are being used for fishing because they are stronger than normal nets and do not disintegrate. This is especially prevalent in Kenya and Zambia, but is a problem in many other countries as well. According to malariaworld.org, "This phenomena has caused an increase in the malaria prevalence rate along the coastlines of various African countries."
Sunday, March 6, 2011
I am amazed by people who have lived their whole lives in them but have remained cheerful and happy. As well as the story below about John Prestwich there is also the story of Martha Mason who has lived in an ironlung for over 60 years.
(A)s one of the few surviving people left who live their lives encased in an iron tank, she said she intends to continue as she always has -- making the most out of what life has offered her.
"Get as much joy from life for yourself and others as you can squeeze out of it," she said.
Saturday, March 5, 2011
However, he does not have to live in the iron lung all the time. With modern technology, people designed a smaller machine that he can use at home. The new machine is the size of his chest and performs almost the same exact functions as the large iron lung.
Prestwich also shares parts of his personal story:
Friday, March 4, 2011
Thursday, March 3, 2011
In June of 2010, the nonprofit Malaria No More wanted to encourage people to use bed nets in order to prevent malaria. On June 9, 2010 in Dakar, Senegal nine finalists took to the stage to vie for a recording deal. All of the songs sung were written by the contestants and they were all on the topic of prevent malaria. The idea behind the campaign is simple and brilliant: if you’re working in public health and you want to change people’s behavior for the better, don’t try to convince them yourselves. Instead, find someone outside the medical community who already knows how.
The video above was recorded by one of Senegal's biggest pop stars. It is a cautionary tale about protecting yourself from malaria. It was released with a special concert the night before the Senegalese government kicked off a massive distribution of bed nets for all children younger than 5.
Not everyone agrees that bednets should be the main focus of our malaria eradication campaign. This video raises a number of very good points, particularly that the western world eliminated malaria via the use of DDT, a tool we now deny to other countries.
For further reading on the issue of using pesticides such as DDT check out Tina Rosenberg's controversial article in the New York Times: What the world needs now is DDT.
Also, it is interesting to note that even Rachel Carson, whose book Silent Spring sounded the alarm on the environmental dangers of DDT, did not call for a total ban on DDT:
Practical advice should be "Spray as little as you possibly can" rather than "Spray to the limit of your capacity."
Unfortunately because we did the latter we eventually saw environmental consequences and ultimately banned DDT, but only after we had eliminated malaria. Is it right to deny this tool to other countries, even its appropriate use, because we screwed up?
In this new campaign by Malaria No More, comedians including Elizabeth Banks and Aziz Ansari come together to end malaria deaths in Africa by 2015. Listen to the luminaries share their childhood dreams in this PSA.
View the 1 minute campaign clip for a light-hearted yet inspirational step in the cause of putting a stop to malaria.
Then take a look at the Malaria No More webpage--a site promoting the Malaria No More campaign. Malaria is a preventable and treatable disease and recent progress shows that malaria's days are numbered — but our help is needed. Together, we can make malaria no more. As seen in the video clip, Hollywood icons are using their powerful voices to make a difference. As part of the campaign, a large group of them are hosting "Hollywood Bites Back!," a live comedy show on April 16 at Nokia Theatre in L.A. to benefit Malaria No More.
Wednesday, March 2, 2011
(A) majority of Americans said they favor cutting U.S. foreign aid, but more than 6 in 10 opposed cuts to education, Social Security, and Medicare. Smaller majorities objected to cutting programs for the poor, national defense, homeland security, aid to farmers, and funding for the arts and sciences.
One of the explanations for this rather ungenerous attitude is that the US public vastly over estimates how much money the government actually gives in foreign aid. This, again, has been shown by several research polls and seems to be a fairly consistent result. (Interestingly, and perhaps logically, people greatly underestimate how much of the US budget goes to other sources such as Medicare/Medicaid and defence.)
The only good news I can give you is that according to Kaiser Family Foundation 2010 Survey of Americans on the U.S. Role in Global Health when the specific purpose of the foreign aid is explained it is more likely to be supported.
When it comes to U.S. foreign aid in general, six in 10 Americans (61%) say the U.S. spends too much, and four in 10 incorrectly think that foreign aid is one of the two biggest areas of spending in the federal budget. In comparison, when asked about “improving health in developing countries,” 28 percent say the U.S. spends too much, while nearly two thirds say such spending is too little (23%) or about right (42%).
“The old canard that most Americans do not support ‘foreign aid’ is a misunderstanding of how the public really feels,” said Kaiser President and CEO Drew Altman. “When the specific purposes of spending abroad are put before the public, Americans are more supportive of health and development funding.”
Tuesday, March 1, 2011
The main goal of this research was to examine the features of this disease from a mechanical point of view. Through their research the team has discovered that the red blood cells that are affected by the parasite Plasmodium falicparum were far stiffer and more adhesive than healthy red blood cells. They stretched the cells in order to examine their elastic properties and saw that these infected cells were 10-20 times stiffer than normal cells.
Since red blood cells have to be fast messengers, traveling quickly through the capillaries, these stiffer cells cannot travel at the same speed. Also, since the cells become adhesive they tend to travel closer to the walls of the arteries while healthy red blood cells travel through the center. These two characteristics of the infected blood cells cause these red blood cells to stick to the capillaries in the brain, thus causing them to not reach the spleen. The spleen is responsible for filtering parasites from the blood. These infected red blood cells are unable to transport nutrients and oxygen to the rest of the body.
These discoveries could provide information extremely valuable to treating malaria.
While searching for something malaria-related to post on the blog this week I stumbled upon this site: Malaria Site. The website has numerous fascinating sections dedicated to the history of malaria including reports on the earliest written descriptions of malaria dating back thousands of years ago to Babylonian cuneiform tablets which attribute the disease to Nergal, the Babylonian god of destruction and pestilence (described as a double-winged, insect).
A spoonful of sugar may help the medicine go down, but why bother when you could just give patients chocolate? That's what Bill Gates wants to do.
Through the Bill & Melinda Gates Foundation, he's given $100,000 in grants each to scientists who want to use candy to diagnose and treat malaria. UCLA doctoral candidate Andrew Fung received a grant to use gum to detect malaria indicators in saliva, making the test painless. Steven Maranz, a researcher at Weill Cornell Medical College will use his money to study the effects of chocolate, which binds to and removes the cholesterol the malaria parasite needs to survive from the bloodstream. Maranz thinks chocolate may be able to kill most parasites while leaving enough in the blood to help children develop a lifetime resistance. The five-year grants for malaria are part of the foundation's Grand Challenges Exploration program, which also gave $100,000 to 74 other unconventional approaches to world problems.
from an article dated October 2009